Insider News

I’ve noticed it is t1d blog week, but with a hell of a lot of other things going on in my life, and I know I’ve been slacking. I hope my readers understand, and that I post enough throughout any typical week that you’ll let me slide!

I received this email today from JDRF. I think it’s important to share all the research that is going on for Type 1 Diabetes. If you haven’t noticed, I am an advocate for t1d research. Hopefully one day soon, I will have an artificial pancreas that will monitor my blood sugar levels and give me insulin without me needing to lift a finger. I really would like to get involved in some of this research, so if anyone is looking for candidates, email me!

Check out the article below about some new advances from JDRF.

JDRF: Insider News

Artificial Pancreas

New JDRF-Funded Technology in Collaboration with BD and Helmsley Charitable Trust Offer Improved Insulin Delivery with Less Pain

Today we celebrate a significant achievement in the fight against T1D. Becton Dickinson Medical announced that the U.S. Food and Drug Administration approved its application to begin production of its novel FlowSmartTM insulin infusion set. This important accomplishment would not have been possible without help from our many supporters. We are extremely grateful to our donors, partners and the entire T1D community.

The new infusion set is designed for use with insulin pumps sold in the U.S., and studies show that it has significantly fewer flow interruptions and blockages than regular sets. The smaller needle also causes less insertion site trauma.

Infusion sets are a critical part of effective insulin-pump therapy, yet these sets have seen little innovation over the years. More than six years ago, JDRF Research and BD Diabetes Care leadership helped bridge that gap through a multi-year partnership with BD and a seven-figure investment by JDRF and the Helmsley Charitable Trust to develop FlowSmart technology.

This new infusion technology could play an important role in developing highly reliable and effective artificial pancreas systems, which aim to require little monitoring and action on the part of the user. JDRF donors helped make possible this important step towards creating a world without T1D.

Read about ways to support JDRF here.

World Diabetes Day

Today is World Diabetes Day and I am participating in a 14-14-14 challenge by taking 14 minutes on November 14th and sending out 14 emails to help create a world without Type 1 Diabetes. You can help me and JDRF make this a successful campaign by making a donation here.

JDRF is turning Type One into Type None…with not just a vision, but a plan. JDRF is the only global organization with a strategic research plan to end Type 1 Diabetes (T1D). Their plan will create a future where:

  • Blood-glucose levels can be controlled automatically
  • A T1D can sleep, eat, exercise, and live as if T1D is not in their lives
  • T1D can be prevented and never threaten anyone again
  • T1D can be cured

Please help me by making a 100% tax-deductible donation to my team. Over 80% of the funds raised by JDRF directly support research and related education. Thanks in advanced for your support.

Fall Kick-Off

Happy Labor Day!

In my efforts to ‘kick off’ the fall season, I have launched a new t-shirt campaign. Profits from the campaign will go directly to JDRF in the 2014 Walk to Cure Diabetes. Take a look at the shirt below, and give me feedback as to what you would like to see in the future.

Diabetics: The Only People who Take Drugs to Avoid Getting High | www.iamatype1diabetic.comWhat makes you not want to buy it? What makes you want to buy it?  Any suggestions of different t-shirts? I’m open to all suggestions!

#icebucketchallenge

I haven’t yet been nominated for the ALS #icebucketchallenge, but that’s perfectly fine with me!

I think we need to start a promotion like this for JDRF instead — a much more near and dear foundation for me and many of my friends (and I’m assuming a good amount of my blog readers too).

I want to start a new challenge in order to begin my efforts in raising money for the 2014 JDRF Walk to Cure Diabetes at Yonkers Raceway on October 26th. This will be my 13th year walking with my team Calla’s Crusaders, and my second JDRF walk for this year. Calla’s Crusaders previously raised over $4500 in Buffalo, NY in June. We need money to help fund research, make live’s of type 1 diabetics easier and hopefully find a cure. Any efforts to raise money for the JDRF foundation is something I will always take part in.

What could be a better idea instead of an Ice Bucket Challenge? What other fad could we start up to raise awareness for diabetes (both type 1 and type 2)? I will accept (almost) any challenge that you may give me — and have some fun by doing it.

If you don’t have any challenge ideas, could you simply donate? www.callascrusaders.com

Your Funding

Medical Devices created by JDRF Funding

This just happened! Paul Tatu is holding the encapsulation device, which is going into human clinical trials this year! If you have raised funds or donated to a JDRF event, THIS is what YOUR fundraising has helped accomplish!

Thank you to everyone who has ever donated or walked with JDRF. Sometimes it’s the little things in life that make a huge difference. I am very appreciative of all my donations, and as always, I am taking donations on www.callascrusaders.com for JDRF.

Thank You!

This past Sunday, June 8th, approximately 3,200 members of the Buffalo community came together to create a world without type 1 diabetes (T1D). Our team, Calla’s Crusaders had about 45 people who joined us and helped to raise money. This was our 13th Walk to Cure Diabetes together. What an incredible Walk day!

Thanks so much to my team in your fundraising efforts. To all of those who donated, thank you for helping us make a great impact in research efforts to turn type one into type none! Our online fundraising website will remain open throughout June & July. Visit www.callascrusaders.com to donate and find out more about why participate in the walk.

Thank you once again for your efforts. JDRF is the only global organization with a strategic plan to deliver a continuous flow of life-changing therapies and, ultimately, a cure for people living with T1D. Without your help, we couldn’t drive progress from advances in the lab to life-changing therapies for people with T1D.

Our Calla's Crusaders Walk team in the 2014 Walk to Cure Diabetes | www.iamatype1diabetic.com

 

These are the type 1 diabetics of team Calla’s Crusaders:

Living with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.comLiving with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.com

And here are some other snapshots of our day. Thanks again for all your support!
Living with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.com  Living with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.comLiving with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.comLiving with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.comLiving with Type 1 Diabetes & Walking for JDRF to find a cure | www.iamatype1diabetic.com

Limited Time Offer

I am doing an online promotion to raise money for type 1 diabetes.  I am selling these t-shirts, tank tops and sweatshirts for a limited time in order to jumpstart my 2014 Walk to Cure Diabetes fundraising!

Please click here to order yours now! Offer expires on May 21st.

Of course, if you don’t want the shirt, and want to donate online to me directly, you can do so by clicking here.

Aren’t these cute? Calla’s Crusaders – Fighting to find  a cure for Type 1 Diabetes.

Limited Time Offer - 2014 Calla's Crusaders T-shirts - Walk to Cure Diabetes | www.iamatype1diabetic.comLimited Time Offer - 2014 Calla's Crusaders T-shirts - Walk to Cure Diabetes | www.iamatype1diabetic.comLimited Time Offer - 2014 Calla's Crusaders T-shirts - Walk to Cure Diabetes | www.iamatype1diabetic.com

2014 Walk to Cure Diabetes

I’ve been doing the Western NY Chapter and the Westchester County Chapter JDRF Walk to Cure Diabetes since 2001. It’s that time of the year again to begin my efforts for the Western New York Chapter being held at Delaware Park in Buffalo, NY on June 8th, 2014.

My team is Calla’s Crusaders and we are taking steps to help JDRF achieve its goal of improving the lives of all people affected by type 1 diabetes (T1D) by accelerating progress on the most promising opportunities for curing, better treating, and preventing T1D. By joining our walk team or making a donation, you will be helping us to raise funds to directly support research with the greatest potential to conquer this disease.Make A Donation to JDRF and support Calla's Crusaders in the 2014 Walk to Cure Diabetes | www.iamatype1diabetic.com

teamwalkpage

The JDRF Walk to Cure Diabetes is a fun, happy, healthy, and effective way to show your support for all those living with type 1 diabetes (T1D) and to raise funds for JDRF—the leading global organization focused on T1D research.

Calla Rusch, the team captain, has been a type 1 diabetic (T1D) for the last 17 years, since she was 9 years old. She is currently on an OmniPod insulin pump, which controls blood sugars levels better, but still is not a cure for diabetes. She also uses the Dexcom CGM to continuously monitor her blood sugar levels.
Watch My Diabetes Story | www.iamatype1diabetic.com

We are motivated by the courage and perseverance of those facing the everyday challenges of type 1 diabetes – they are the reason we challenge ourselves to give more, to do more, to achieve more. We challenge ourselves to make a real difference in the lives of those with T1D.

This year, I am expanding my efforts to raise money for JDRF by selling our specially made Calla’s Crusaders T-Shirts online. As of right now, they are pre-sale and will be available for shipping sometime in May.

Buy a Calla's Crusaders T-Shirt to Show Diabetes Support | www.iamatype1diabetic.com

2014 Walk to Cure Diabetes

We are taking steps to help JDRF achieve its goal of improving the lives of all people affected by type 1 diabetes (T1D) by accelerating progress on the most promising opportunities for curing, better treating, and preventing T1D. By joining our Walk Team and making a donation, you will be helping us to raise funds to directly support research with the greatest potential to conquer this disease.

Calla Rusch, the team captain, has been a type 1 diabetic (T1D) for the last 17 years, since she was 9 years old. She is currently on an OmniPod insulin pump, which controls blood sugars levels better, but still is not a cure for diabetes. She also uses a Dexcom CGM to continuously monitor her blood glucose (sugar) levels.

Many people think type 1 diabetes can be controlled by insulin. While insulin does keep people with type 1 diabetes alive, it is NOT a cure, just a temporary solution. There are many daily challenges for people living with type 1 diabetes, there are many severe, often fatal, complications caused by the disease. Type 1, or juvenile, diabetes, is a devastating, often deadly disease that affects millions of people–a large and growing percentage of them children.

Click here to watch Calla’s story: http://www.youtube.com/iamatype1diabetic

We are motivated by the courage and perseverance of those facing the everyday challenges of type 1 diabetes – they are the reason we challenge ourselves to give more, to do more, to achieve more. We challenge ourselves to make a real difference in the lives of those with T1D.
Will you accept the challenge to make a difference? All you need you to do is click on the “Donate” button, make a donation, and pass along to your friends and family. It’s simple, fast, and fun!

All donations are tax deductible. Thank you for your support and for helping JDRF to create a world without T1D.

Donate to JDRF - Calla's Crusaders | www.iamatype1diabetic.comJoin Calla's Crusaders in the Walk to Cure Diabetes | www.iamatype1diabetic.com

Countdown to None

Countdown to None | A World Without Type 1 Diabetes | www.iamatype1diabetic.com

Your support of JDRF’s plan to turn Type One into Type None has led to real progress. Because of you, research advances like these are possible. Thank you for your commitment to JDRF.

IMMUNE CELLS PROMOTE BETA CELL GROWTH

Developing therapies to regenerate beta cells lost in T1D is a high priority for JDRF, as they could help people with the disease achieve insulin independence. Now, JDRF-funded researchers at Joslin Diabetes Center are closer to that goal.

Data from Joslin’s 50-Year Medalist Study has shown that some people retain some beta cells decades after their diagnosis. Researchers have long suspected that immune cells may play a role in beta cell preservation, but exactly how remained a mystery.

In a first-of-its-kind study, Joslin scientists injected nonobese diabetic (NOD) mice with immune cells—subtypes of T cells and B cells—from the pancreatic islets of donor NOD mice. They observed that beta cell growth occurred after the host islets were infiltrated by the immune cells, and that it is specifically the T cells, not the B cells, that are associated with that growth. Further, they found that the immune cells secrete inflammatory cytokines and chemokines—signaling proteins—that work together to enhance beta cell growth.

These results are encouraging. The investigators will next move on to human beta cells and aim to determine whether those signaling proteins can be harnessed to elicit beta cell proliferation.

PREVENTING T1D WITH ANTICANCER DRUGS

Repurposing drugs indicated for other diseases is one of JDRF’s approaches to accelerating the delivery of new therapies to people with T1D. A recent JDRF-funded study in mice determined that low doses of a cancer drug protect against the development of T1D—bringing us one step closer to a potential preventive treatment.

Researchers at three Danish universities investigated lysine deacetylase inhibitors—a well-tolerated class of lymphoma drugs—because of their ability to block the molecules that send harmful inflammation signals to pancreatic beta cells. Extremely low doses—doses 100 times lower than those used in cancer treatment—protected the mice’s beta cells from the destructive effects of inflammation and ultimately prevented the development of T1D in the mice. In additional tests, this time on insulin-producing human donor tissues already exposed to the inflammation, the drug delayed the destruction of beta cells.

The next step for the research team is to test the drug on those at risk of developing T1D. JDRF will work closely with the investigators as they move forward with this critical step in the translational research process, which is a key part of JDRF’s plan to create a world without T1D.